Rosemary Harris and Cliff Robertson
In 2002's Spider-Man, Tobey Maguire was a 27-year-old actor playing a High School student, being raised by veteran actors Rosemary Harris and Cliff Robertson. In this version Peter leaves High School almost immediately after gaining control of his power, which must make him an 18-year-old.
Looking at Harris and Robertson's ages during filming we can assume:
Aunt May's Age During Movie: 75
Uncle Ben's Age During Movie: 79
Aunt May's Age at Peter's Birth: 57
Uncle Ben's Age at Peter's Birth: 61
So either Richard Parker was exceedingly old when he had Peter, or he was much younger than his brother.
Sally Field and Martin Sheen
After Sam Raimi left the franchise, Sony rebooted Spider-Man with Andrew Garfield and two iconic actors playing his adoptive parents: Sally Field and Martin Sheen. Garfield was once again a 20-something playing a High School student, but Field and Sheen both skewed younger:
Aunt May's Age During Movie: 66
Uncle Ben's Age During Movie: 72
Since he doesn't graduate until the sequel, we're estimating that Peter is 17 during Amazing Spider-Man:
Aunt May's Age at Peter's Birth: 49
Uncle Ben's Age at Peter's Birth: 55
Marisa Tomei and ???
This version of Spider-Man should be pretty different. Since Peter Parker is donning the suit for next year's Captain America: Civil War, we most likely won't see Uncle Ben pre-robbery turned manslaughter, which is totally fine. If we have to see that scene ever again, it'll be too soon (hint hint: Thomas and Martha Wayne).
Since Tom Holland is 19, this will be a much younger Peter, who will probably spend a couple more movies before graduating (think Hogwart's but with web-slinging instead of spell-casting). How will Marisa stack up in this youthful Spider-Man movie?
Aunt May's Age During Movie: 53
If we assume Peter will begin this movie as a 16-year-old:
Aunt May's Age at Peter's Birth: 37
Frankly, this seems a lot more plausible than the geriatrics in Spider-Man (2002). What do you think? Is Marisa Tomei the right age for Aunt May?