The Binding of Isaac and re-built it from scratch, complete with local co-op, competitive loadouts and more than two playable characters.
"Rebirth isn't a Flash game – it's made in an engine created by the game's console publisher, Nicalis, with brand new SNES-style, semi-16-bit graphics. The new game has more than 110 new items, extra gameplay, enemies and bosses, plus an expanded storyline."