To call wood frogs hardy would be an understatement. The species (Rana sylvatica) can survive winter temperatures that freeze up to two-thirds of the water in their bodies. They endure this annual popsicle phase with help from cryoprotectants, substances circulating in their blood that lower the freezing point of their body fluids. New research shows that frogs at the northern limits of the species' range are uniquely adapted to freezing.
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